Chief Wilson's 36 triples in 1912 Barry Bonds' 232 walks in 2004 Rose's 4,256 career hits
Some of the career ones are so untouchable that they're not even worth discussing (511 wins, etc).
I think most of the single season ones could be broken, and the triples one is a good one. Most since 1950 is 23 from Granderson.
I actually think some of the career ones are in greater jeopardy of being broken than the single season ones due to all the T-800s who will be playing baseball within the next couple three years.
most career innings pitched (7,356) most career games started (815) most complete games (749) most losses (316)
Here is another great one for pitchers that will never be touched...
The record for complete games in a live-ball season is 33, set at the dawn of the era by Grover Cleveland Alexander in 1920 and Burleigh Grimes in 1923, and also by Dizzy Trout in 1944, when baseball's player pool was severely diluted due to World War II.